Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.79 |
| ▸ | MMP1 | P03956 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | ACACA | Q13085 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7181803 | 1.00 | MMP13 (0.79) | MMP13MMP1MMP2ALDH1A1POLB | |
| SCHEMBL7182155 | 0.88 | MMP13 (1.00) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL5125714 | 0.87 | MMP13 (0.59) | MMP13ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5125706 | 0.87 | MMP13 (0.59) | MMP13ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7869955 | 0.86 | MMP13 (0.60) | MMP13MMP1MMP2ALDH1A1MMP9 | |
| SCHEMBL7180333 | 0.83 | MMP13 (0.82) | MMP13MMP1 | |
| SCHEMBL7292055 | 0.83 | MMP13 (0.56) | MMP13ALDH1A1SMN1; SMN2 | |
| SCHEMBL7183683 | 0.81 | MMP13 (0.79) | MMP13MMP1MMP2ALDH1A1MMP3 | |
| SCHEMBL7183687 | 0.81 | MMP13 (0.79) | MMP13MMP1MMP2ALDH1A1MMP3 | |
| SCHEMBL7187265 | 0.80 | MMP13 (0.52) | MMP13MMP1MMP2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583299-B1 | Matrix metalloprotease inhibitors; nonsuppression of tumor necrosis factor production | G.D. SEARLE & CO. | 2003-06-24 | — | — | US | disclosed |
| EP-1178959-A1 | ALPHA-AMINO-BETA-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071514-A1 | α-AMINO-β-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2000-11-30 | — | — | WO | disclosed |