Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.78 |
| ▸ | MMP1 | P03956 | 9/20 | 0.67 |
| ▸ | MMP2 | P08253 | 6/20 | 0.49 |
| ▸ | MMP9 | P14780 | 4/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183525 | 0.85 | MMP13 (0.63) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7301867 | 0.83 | MMP13 (0.80) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL7301855 | 0.83 | MMP13 (0.80) | MMP13MMP1MMP2MMP9MMP3 | |
| Hydrochloric Acid SCHEMBL7308866 | 0.82 | MMP13 (0.79) | MMP13MMP1MMP2MMP9MMP3 | |
| Hydrochloric Acid SCHEMBL7308854 | 0.82 | MMP13 (0.79) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6764610 | 0.78 | MMP13 (0.70) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6764872 | 0.78 | MMP13 (0.70) | MMP13MMP1MMP2MMP9MMP3 | |
| SCHEMBL6764875 | 0.78 | MMP13 (0.70) | MMP13MMP1MMP2MMP9MMP3 | |
| Hydrochloric Acid SCHEMBL7301537 | 0.76 | MMP13 (0.67) | MMP13MMP1MMP2MMP9MMP3 | |
| Hydrochloric Acid SCHEMBL7301531 | 0.76 | MMP13 (0.67) | MMP13MMP1MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583299-B1 | Matrix metalloprotease inhibitors; nonsuppression of tumor necrosis factor production | G.D. SEARLE & CO. | 2003-06-24 | — | — | US | disclosed |