SCHEMBL7182278

SCHEMBL7182278

CCCP(=O)(C(=O)c1c(C)cc(C)cc1C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.41
LMNA P02545 3/20 0.41
CFTR P13569 1/20 0.41
KMT2A Q03164 5/20 0.40
MEN1 O00255 4/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HPGD P15428 1/20 0.40
POLB P06746 1/20 0.38
ALDH1A1 P00352 1/20 0.37
CRHR1 P34998 2/20 0.37
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182680 0.91 TSHR (0.41) L3MBTL1LMNACFTRKMT2AMEN1
SCHEMBL7180466 0.90 CETP (0.43) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL7181107 0.89 L3MBTL1 (0.42) L3MBTL1LMNACFTRKMT2AMEN1
SCHEMBL7189114 0.89 CETP (0.45) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL7178304 0.89 CETP (0.45) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL7187160 0.89 CETP (0.45) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL7186592 0.89 CETP (0.45) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL6031070 0.88 NPSR1 (0.43) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL1138267 0.88 KMT2A (0.42) LMNACFTRKMT2AMEN1SMN1; SMN2
SCHEMBL7179807 0.87 LMNA (0.39) L3MBTL1LMNACFTRKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017120743-A1 SILICONE-COMPATIBLE COMPOUNDS Henkel IP & Holding GmbH (DE) 2017-07-20 WO disclosed
CN-1200943-C Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2005-05-11 CN disclosed
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed
CN-1308081-A Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2001-08-15 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 L3MBTL1 302/4885LMNA 3241/4885CFTR 2596/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 L3MBTL1 126/4885LMNA 3247/4885CFTR 3551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.