Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092607 | 0.87 | MAPK1 (0.47) | HRH3LTA4HMAPK1LMNAGAA | |
| SCHEMBL2090463 | 0.86 | MAPK1 (0.51) | HRH3MAPK1LMNAGAATSHR | |
| SCHEMBL2090464 | 0.86 | MAPK1 (0.51) | HRH3MAPK1LMNAGAATSHR | |
| SCHEMBL9323597 | 0.81 | SIGMAR1 (0.68) | LTA4HMAPK1LMNAGAATSHR | |
| SCHEMBL15759176 | 0.81 | LTA4H (0.63) | HRH3LTA4HMAPK1LMNAGAA | |
| SCHEMBL11586577 | 0.80 | MAPK1 (0.51) | MAPK1LMNAGAATSHRL3MBTL1 | |
| SCHEMBL11586576 | 0.80 | MAPK1 (0.51) | MAPK1LMNAGAATSHRL3MBTL1 | |
| SCHEMBL14924490 | 0.79 | LTA4H (0.61) | HRH3LTA4HMAPK1LMNAGAA | |
| SCHEMBL29253444 | 0.79 | LTA4H (0.61) | HRH3LTA4HMAPK1LMNAGAA | |
| SCHEMBL18085065 | 0.79 | LTA4H (0.61) | HRH3LTA4HMAPK1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |