Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7195408 | 0.92 | ESR1 (0.51) | ESR1ESR2NPC1L3MBTL1LTB4R | |
| SCHEMBL7187504 | 0.85 | CA12 (0.56) | ESR1ESR2BACE1 | |
| SCHEMBL7182549 | 0.84 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7182543 | 0.84 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7189415 | 0.81 | ESR1 (0.48) | ESR1ESR2BACE1 | |
| SCHEMBL7189412 | 0.81 | ESR1 (0.48) | ESR1ESR2BACE1 | |
| SCHEMBL7190060 | 0.79 | ESR1 (0.40) | ESR1ESR2NPC1LTB4R2 | |
| SCHEMBL7189519 | 0.79 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL7189979 | 0.78 | ESR1 (0.51) | ESR1ESR2NPC1 | |
| SCHEMBL7183993 | 0.78 | ESR1 (0.59) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |