Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indomethacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 11/20 | 0.73 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.73 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.73 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | PTGES | O14684 | 1/20 | 0.73 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.73 |
| ▸ | ALB | P02768 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indomethacin SCHEMBL6827247 | 0.93 | PTGS2 (0.63) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL5039684 | 0.90 | PTGS2 (0.73) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL11570993 | 0.88 | PTGS2 (0.79) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL356273 | 0.88 | PTGS2 (0.79) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL28072579 | 0.86 | PTGS2 (0.98) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL28285479 | 0.85 | PTGS2 (0.88) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL27521872 | 0.85 | PTGS2 (0.92) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL3518614 | 0.85 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL29525957 | 0.85 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2HIF1APTGS1 | |
| Indomethacin SCHEMBL9300 | 0.85 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2HIF1APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320149-A1 | ANTIBODIES TARGETING COMPLEMENT FACTOR D AND USES THEROF | Takeda Pharmaceutical Company Limited (JP) | 2024-02-14 | — | — | EP | disclosed |
| US-20240034779-A1 | ANTIBODIES TARGETING COMPLEMENT FACTOR D AND USES THEROF | SHIRE HUMAN GENETIC THERAPIES, INC. | 2024-02-01 | — | — | US | disclosed |
| CN-110022949-A | DEVICES, SYSTEMS, AND METHODS FOR TRAINING PELVIC FLOOR MUSCLES | 锐诺维公司 | 2019-07-16 | — | — | CN | disclosed |
| US-20190085095-A1 | ANTI-C5 ANTIBODIES WITH ENHANCED PH SWITCH | SHIRE HUMAN GENETIC THERAPIES, INC. | 2019-03-21 | — | — | US | disclosed |
| EP-3408291-A1 | ANTI-C5 ANTIBODIES WITH ENHANCED PH SWITCH | Shire Human Genetic Therapies, Inc. (US) | 2018-12-05 | — | — | EP | disclosed |
| WO-2017132259-A1 | ANTI-C5 ANTIBODIES WITH ENHANCED PH SWITCH | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2017-08-03 | — | — | WO | disclosed |
| US-6572888-B2 | Reduce glucose concentartion; diabetes therapy | MEDICAL RESEARCH INSTITUTE | 2003-06-03 | — | — | US | disclosed |
| US-20010028896-A1 | Controlled release lipoic acid | NATURE ACQUISITION LLC | 2001-10-11 | — | — | US | disclosed |
| US-5656284-A | PLACING TABLET COMPRISING PHARMACEUTICAL AND EXCIPIENT NOT READILY SOLUBLE IN SALIVA IN MOUTH BETWEEN LIP AND GINGIVAL MUCOSA, ALLOWING TO REMAIN TO DELIVER PHARMACEUTICAL | TRANSAMERICA BUSINESS CREDIT CORP. | 1997-08-12 | — | — | US | disclosed |
| US-4455146-A | THERMOPLASTIC ELASTOMERS, OILS OR FATTY ACID, TACKFIER, AND A MEDICINE | HISAMITSU PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |