SCHEMBL7183285

SCHEMBL7183285

O=C(NCc1ccccc1)c1cccc(C(=O)NCc2ccccc2)c1C(=O)NCc1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.71
HPGD P15428 3/20 0.67
GAA P10253 2/20 0.67
LMNA P02545 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
APEX1 P27695 1/20 0.66
METAP2 P50579 1/20 0.65
CHRNB2 P17787 1/20 0.65
CHRNB4 P30926 1/20 0.65
CHRNA3 P32297 1/20 0.65
CHRNA4 P43681 1/20 0.65
NSD2 O96028 3/20 0.64
TSHR P16473 1/20 0.64
TP53 P04637 1/20 0.61
GLA P06280 1/20 0.61
SGMS2 Q8NHU3 1/20 0.59
CYP2C19 P33261 2/20 0.57
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.55
CYP2C9 P11712 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31680569 0.88 KMT2A (0.89) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL11901003 0.88 KMT2A (0.89) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL1984940 0.83 KMT2A (1.00) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL8635709 0.83 KMT2A (1.00) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL27903143 0.82 HDAC2 (0.73) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL3192733 0.82 KMT2A (0.67) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL6720193 0.82 KMT2A (0.77) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL1979028 0.81 KMT2A (0.71) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL5620857 0.81 PPIA (0.76) KMT2AHPGDGAALMNAL3MBTL1
SCHEMBL17686276 0.80 HPGD (1.00) KMT2AHPGDGAALMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1366116-A2 POLYPROPYLENE RESIN COMPOSITIONS Ciba SC Holding AG (CH) 2003-12-03 EP disclosed
WO-2002046300-A2 POLYPROPYLENE RESIN COMPOSITIONS CIBA SPECIALITY CHEMICALS HOLDING INC. (CH) 2002-06-13 WO disclosed