Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31645593 | 0.87 | KDM1A (0.60) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL4533547 | 0.87 | KDM1A (0.60) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL4667179 | 0.84 | MCL1 (0.61) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL7183438 | 0.84 | KDM1A (0.58) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL9902123 | 0.83 | LMNA (0.91) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL10027919 | 0.82 | LMNA (0.52) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL8659813 | 0.81 | LMNA (0.88) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL4667208 | 0.81 | STAT3 (0.64) | KDM1AMCL1CDK1CDK2IRAK4 | |
| SCHEMBL13525181 | 0.81 | MCL1 (0.55) | LMNAMCOLN3CA12CA2CA9 | |
| SCHEMBL4699013 | 0.81 | SLC22A12 (0.55) | KDM1AMCL1CDK1CDK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | disclosed |