Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183491 | 1.00 | PKM (0.55) | PKMMAPK1NPSR1HCAR3STAT3 | |
| SCHEMBL1015485 | 0.86 | HCAR3 (0.53) | HCAR3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1015486 | 0.86 | HCAR3 (0.53) | HCAR3MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL16989691 | 0.85 | HCAR3 (0.52) | PKMMAPK1HCAR3MAPTALDH1A1 | |
| SCHEMBL15599592 | 0.85 | HCAR3 (0.52) | PKMMAPK1HCAR3MAPTALDH1A1 | |
| SCHEMBL2860350 | 0.84 | MAPK1 (0.58) | PKMMAPK1NPSR1HCAR3STAT3 | |
| SCHEMBL18687361 | 0.83 | HCAR3 (0.50) | MAPK1NPSR1HCAR3MAPTALDH1A1 | |
| SCHEMBL4437146 | 0.82 | MAPT (0.64) | MAPK1NPSR1MAPTALDH1A1MEN1 | |
| SCHEMBL7177008 | 0.82 | HCAR3 (0.49) | HCAR3MAPTMEN1KMT2A | |
| SCHEMBL7176994 | 0.82 | HCAR3 (0.49) | HCAR3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |