Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183760 | 1.00 | MTHFD2 (0.40) | MTHFD2CCR2OPRM1LMNAGAA | |
| SCHEMBL7188682 | 0.91 | CYP3A4 (0.42) | CCR2OPRM1PRMT5WDR77C5AR1 | |
| SCHEMBL7188706 | 0.91 | CYP3A4 (0.42) | CCR2OPRM1PRMT5WDR77C5AR1 | |
| SCHEMBL7182967 | 0.89 | PDE7A (0.44) | PRMT5WDR77C5AR1 | |
| SCHEMBL7185263 | 0.89 | PDE5A (0.47) | PRMT5WDR77 | |
| SCHEMBL7182960 | 0.89 | PDE7A (0.44) | PRMT5WDR77C5AR1 | |
| SCHEMBL7178544 | 0.89 | PDE5A (0.47) | PRMT5WDR77 | |
| SCHEMBL7178553 | 0.89 | PDE5A (0.47) | PRMT5WDR77 | |
| SCHEMBL7191279 | 0.87 | DRD4 (0.43) | LMNAGAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL7191286 | 0.87 | DRD4 (0.43) | LMNAGAAMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |