Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 3/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188706 | 1.00 | CYP3A4 (0.42) | CYP3A4CYP2D6HSD11B1CCR2MDM2 | |
| SCHEMBL7183760 | 0.91 | MTHFD2 (0.40) | CYP3A4CYP2D6CCR2PRMT5WDR77 | |
| SCHEMBL7183765 | 0.91 | MTHFD2 (0.40) | CYP3A4CYP2D6CCR2PRMT5WDR77 | |
| SCHEMBL7176915 | 0.90 | CYP3A4 (0.47) | CYP3A4CYP2D6CCR2DRD2OPRM1 | |
| SCHEMBL7176913 | 0.90 | CYP3A4 (0.47) | CYP3A4CYP2D6CCR2DRD2OPRM1 | |
| SCHEMBL7188245 | 0.86 | CYP3A4 (0.40) | CYP3A4CYP2D6HSD11B1CCR2MDM2 | |
| SCHEMBL7188239 | 0.86 | CYP3A4 (0.40) | CYP3A4CYP2D6HSD11B1CCR2MDM2 | |
| SCHEMBL7182960 | 0.85 | PDE7A (0.44) | MDM2PRMT5WDR77TP53C5AR1 | |
| SCHEMBL7185263 | 0.85 | PDE5A (0.47) | MDM2PRMT5WDR77TP53 | |
| SCHEMBL7178544 | 0.85 | PDE5A (0.47) | MDM2PRMT5WDR77TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |