Sugi Predict

Sugi Predict / Compounds / SCHEMBL7183832

SCHEMBL7183832

SCHEMBL7183832

Cc1cc(C)c(C(=O)C(c2ccccc2)C(C)(C)CC(C)CP=O)c(C)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.34
▸ L3MBTL1 Q9Y468 5/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ATM Q13315 2/20 0.32
▸ NPSR1 Q6W5P4 2/20 0.32
▸ SLC6A2 P23975 2/20 0.32
▸ SLC6A4 P31645 2/20 0.32
▸ SLC6A3 Q01959 2/20 0.32
▸ MEN1 O00255 2/20 0.31
▸ KMT2A Q03164 2/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ BRD4 O60885 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30
▸ LDHA P00338 1/20 0.30
▸ LDHB P07195 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ MCOLN3 Q8TDD5 1/20 0.30
▸ GAA P10253 1/20 0.30
▸ HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7183943 0.92 CYP1A2 (0.33) LMNAL3MBTL1ATMMEN1KMT2A
SCHEMBL7183707 0.89 ATM (0.30) L3MBTL1ATM
SCHEMBL7185628 0.83 TRPM4 (0.36) L3MBTL1MEN1KMT2A
SCHEMBL7189082 0.82 KCNQ2 (0.36) L3MBTL1ATMMEN1KMT2A
SCHEMBL611536 0.81 KDM4E (0.35) L3MBTL1KDM4ENPSR1HPGDMCOLN3
SCHEMBL7183923 0.81 ATM (0.34) L3MBTL1ALDH1A1ATMSLC6A2SLC6A4
SCHEMBL7187536 0.81 CA12 (0.38) LMNAL3MBTL1ALDH1A1ATMMEN1
SCHEMBL7179709 0.80 TDP1 (0.37) L3MBTL1ALDH1A1KDM4EATMMEN1
SCHEMBL7178170 0.77 L3MBTL1 (0.37) LMNAL3MBTL1ALDH1A1KDM4EATM
SCHEMBL7180620 0.76 FABP4 (0.38) LMNAALDH1A1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 LMNA 3241/4885L3MBTL1 302/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 LMNA 3247/4885L3MBTL1 126/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.