Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183953 | 1.00 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL7179611 | 0.82 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL7179604 | 0.82 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL7191677 | 0.82 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL4750867 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL31285855 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL7178523 | 0.80 | JAK2 (0.39) | ALDH1A1SMN1; SMN2OPRM1HSD11B1TNKS | |
| SCHEMBL7178530 | 0.80 | JAK2 (0.39) | ALDH1A1SMN1; SMN2OPRM1HSD11B1TNKS | |
| SCHEMBL7185917 | 0.80 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2OPRM1HSD11B1SIRT2 | |
| SCHEMBL7184352 | 0.80 | TNKS (0.54) | OPRM1HSD11B1SIRT2TNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |