Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | TNKS | O95271 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178523 | 1.00 | JAK2 (0.39) | JAK2JAK3TNKSDGAT1HSD11B1 | |
| SCHEMBL7191692 | 0.84 | ALDH1A1 (0.49) | JAK2JAK3HSD11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7183957 | 0.80 | ALDH1A1 (0.56) | JAK2JAK3TNKSDGAT1HSD11B1 | |
| SCHEMBL7183953 | 0.80 | ALDH1A1 (0.56) | JAK2JAK3TNKSDGAT1HSD11B1 | |
| SCHEMBL7180238 | 0.77 | HSD11B1 (0.39) | JAK2JAK3TNKSHSD11B1ALDH1A1 | |
| SCHEMBL7180232 | 0.77 | HSD11B1 (0.39) | JAK2JAK3TNKSHSD11B1ALDH1A1 | |
| SCHEMBL21811053 | 0.74 | HSD11B1 (0.45) | JAK2JAK3TNKSHSD11B1KCNH2 | |
| SCHEMBL21811052 | 0.74 | HSD11B1 (0.45) | JAK2JAK3TNKSHSD11B1KCNH2 | |
| SCHEMBL7183866 | 0.69 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL16593900 | 0.69 | MEN1 (0.61) | SMN1; SMN2KCNH2CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |