Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7184330 | 0.88 | TNFRSF1A (0.38) | TNFRSF1AABCG2PTPN1TDP1CYP1A1 | |
| SCHEMBL7179060 | 0.88 | CYP1A1 (0.44) | TNFRSF1ACYP1A1CYP1B1MAPTSMN1; SMN2 | |
| SCHEMBL7186169 | 0.86 | CYP1A1 (0.43) | TNFRSF1AABCG2TDP1CYP1A1CYP1B1 | |
| SCHEMBL7186301 | 0.81 | ABCG2 (0.57) | TNFRSF1AABCG2PTPN1CYP1A1CYP1B1 | |
| SCHEMBL5915360 | 0.81 | TNFRSF1A (0.43) | TNFRSF1AABCG2PTPN1CYP1A1CYP1B1 | |
| SCHEMBL7184619 | 0.79 | ABCG2 (0.61) | TNFRSF1AABCG2PTPN1TDP1CYP1A1 | |
| SCHEMBL7184624 | 0.79 | ABCG2 (0.61) | TNFRSF1AABCG2PTPN1TDP1CYP1A1 | |
| SCHEMBL7192248 | 0.77 | ABCG2 (0.55) | TNFRSF1AABCG2PTPN1TDP1CYP1A1 | |
| SCHEMBL7192254 | 0.77 | ABCG2 (0.55) | TNFRSF1AABCG2PTPN1TDP1CYP1A1 | |
| SCHEMBL7186786 | 0.76 | CA1 (0.48) | TNFRSF1AABCG2KRASTDP1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6603046-B1 | The invention is drawn to novel bis-aromatic a, beta -unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria. | LICA PHARMACEUTICALS A/S (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-0634927-B1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | LICA PHARMACEUTICALS AS (DK) | 2001-07-04 | — | — | EP | disclosed |
| US-5985935-A | PARASITICIDES OR BACTERICIDES | STATENS SERUMINSTITUT (DK) | 1999-11-16 | — | — | US | disclosed |