SCHEMBL718459

SCHEMBL718459

O=C1C=CC(=O)N1Cc1cccc2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.58
PTGS2 P35354 1/20 0.58
MGLL Q99685 2/20 0.50
GSK3A P49840 1/20 0.50
GSK3B P49841 1/20 0.50
DAO P14920 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
MAPT P10636 3/20 0.49
HTT P42858 1/20 0.49
CA12 O43570 1/20 0.48
POLB P06746 1/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
FAAH O00519 1/20 0.45
ACHE P22303 1/20 0.45
CA2 P00918 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL719505 0.82 GSK3A (0.53) MGLLGSK3AGSK3BDAOMAPT
SCHEMBL2785687 0.82 PTGS1 (0.73) PTGS1PTGS2MGLLGSK3AGSK3B
SCHEMBL1337353 0.80 CA12 (0.57) DAOL3MBTL1MAPTHTTCA12
SCHEMBL28554314 0.80 DAO (0.49) DAOL3MBTL1MAPTHTTCA12
SCHEMBL30132795 0.77 TGM2 (0.58) MAPTHTTCA12POLBTDP1
SCHEMBL4596097 0.77 TGM2 (0.58) MAPTHTTCA12POLBTDP1
SCHEMBL5081393 0.76 PTGS1 (0.66) PTGS1PTGS2MGLLGSK3AGSK3B
SCHEMBL2655588 0.75 KDM4E (0.49) DAOL3MBTL1MAPTHTTCA12
SCHEMBL7635264 0.74 PIM1 (0.64) GSK3AGSK3BDAOL3MBTL1MAPT
SCHEMBL14303171 0.74 RECQL (0.51) DAOL3MBTL1MAPTHTTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114432301-B Covalent inhibitor derivative and application thereof in treatment of viral infection 北京大学 2024-05-31 CN disclosed
CN-114432301-A Covalent inhibitor derivative and application thereof in treating virus infection 北京大学 2022-05-06 CN disclosed
CN-111793088-A Synthetic method of alkenyl dithiophosphate compound 温州医科大学 2020-10-20 CN disclosed
US-9150414-B2 Nanocomposite and dispersion comprising the same KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2015-10-06 US disclosed
US-20120053288-A1 NANOCOMPOSITE AND DISPERSION COMPRISING THE SAME KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2012-03-01 US disclosed