Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11212986 | 1.00 | LMNA (0.56) | LMNAPOLBHTR2AHRH1KMT2A | |
| Oxalic Acid SCHEMBL9317952 | 0.93 | LMNA (0.54) | LMNAPOLBHTR2AHRH1KMT2A | |
| SCHEMBL54346 | 0.89 | HTR2A (0.59) | LMNAPOLBHTR2AHRH1TDP1 | |
| Phosphine SCHEMBL28948486 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| SCHEMBL12506256 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| Methane SCHEMBL28250836 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| Ammonia Solution, Strong SCHEMBL5683105 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| Ammonia Solution, Strong SCHEMBL10389261 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| SCHEMBL29268835 | 0.87 | HTR2A (0.56) | LMNAPOLBHTR2AHRH1TDP1 | |
| Fumaric Acid SCHEMBL7738495 | 0.87 | HCAR2 (0.53) | LMNAPOLBHTR2AHRH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0962459-B1 | DIACETAL COMPOSITION, PROCESS FOR THE PREPARATION OF THE SAME, NUCLEATING AGENT FOR POLYOLEFINS CONTAINING THE SAME, POLYOLEFIN RESIN COMPOSITIONS, AND MOLDINGS | NEW JAPAN CHEM CO LTD (JP) | 2003-10-01 | — | — | EP | claimed |