Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.44 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11212986 | 0.87 | LMNA (0.56) | LMNAPOLBMEN1KMT2AHTR2A | |
| Bicarbonate SCHEMBL7184926 | 0.87 | LMNA (0.56) | LMNAPOLBMEN1KMT2AHTR2A | |
| Oxalic Acid SCHEMBL9317952 | 0.85 | LMNA (0.54) | LMNAPOLBMEN1KMT2AHTR2A | |
| Phenylpropanol SCHEMBL29031682 | 0.84 | LMNA (0.73) | HCAR2LMNAALDH1A1KDM4ECYP2C19 | |
| Fumaric Acid SCHEMBL8669348 | 0.84 | ESR1 (0.50) | HCAR2LMNAALDH1A1KDM4ECYP2C19 | |
| Fumaric Acid SCHEMBL8867077 | 0.83 | SLC6A2 (0.47) | LMNAALDH1A1CYP2C19CYP3A4TSHR | |
| SCHEMBL54346 | 0.82 | HTR2A (0.59) | LMNAPOLBTAAR1HTR2AHRH1 | |
| SCHEMBL20566315 | 0.81 | CA1 (0.50) | HCAR2LMNAALDH1A1KDM4ECYP2C19 | |
| Ammonia Solution, Strong SCHEMBL5683105 | 0.79 | HTR2A (0.56) | LMNACYP2C19CYP3A4TSHRPOLB | |
| Ammonia Solution, Strong SCHEMBL10389261 | 0.79 | HTR2A (0.56) | LMNACYP2C19CYP3A4TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001012742-A1 | CORRECTION TAPE HAVING DYE MIGRATION BLOCKING PROPERTIES | BIC CORPORATION (US) | 2001-02-22 | — | — | WO | disclosed |