Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179367 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL2339309 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL580661 | 0.82 | PDK1 (0.45) | ABCC9ABCC8KCNJ11KCNJ8CXCR2 | |
| SCHEMBL7185647 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL7183015 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL16722382 | 0.76 | AAK1 (0.42) | KDM4EMAPK1 | |
| SCHEMBL16722381 | 0.76 | AAK1 (0.42) | KDM4EMAPK1 | |
| SCHEMBL7190773 | 0.76 | KAT2B (0.52) | ALDH1A1KMT2A | |
| SCHEMBL7182036 | 0.76 | KAT2B (0.52) | ALDH1A1KMT2A | |
| SCHEMBL16155889 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1GAACXCR2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |