Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185647 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1GAAADRB2ADRB1 | |
| SCHEMBL7190795 | 0.85 | GAA (0.39) | KDM4EALDH1A1GAAADRB2ADRB1 | |
| SCHEMBL7188673 | 0.85 | GAA (0.39) | KDM4EALDH1A1GAAADRB2ADRB1 | |
| SCHEMBL7190961 | 0.81 | HCAR3 (0.53) | ALDH1A1KMT2ATDP1HCAR3 | |
| SCHEMBL7184178 | 0.81 | HCAR3 (0.53) | ALDH1A1KMT2ATDP1HCAR3 | |
| SCHEMBL7185261 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL7179367 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL7182989 | 0.78 | MAPK8 (0.38) | PRKD3MAPK8MAP4K4MINK1TNIK | |
| SCHEMBL7183531 | 0.75 | ALDH1A1 (0.41) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL7191231 | 0.75 | PTGER4 (0.48) | KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |