Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160454 | 0.73 | ALKBH5 (0.39) | ALKBH5NOTUMFLT1KDRS1PR1 | |
| SCHEMBL7155610 | 0.71 | POLB (0.48) | — | |
| SCHEMBL7254837 | 0.70 | AR (0.41) | AR | |
| SCHEMBL16181625 | 0.67 | AR (0.53) | ALKBH5NOTUMPDE3BPDE3AHTR2A | |
| SCHEMBL16181629 | 0.67 | AR (0.53) | ALKBH5NOTUMPDE3BPDE3AHTR2A | |
| SCHEMBL13122994 | 0.66 | AR (0.49) | ALKBH5NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL28166708 | 0.65 | AR (0.48) | ALKBH5NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL13122748 | 0.65 | CYP3A4 (0.50) | NOTUMPDE3BPDE3A | |
| SCHEMBL13122732 | 0.65 | PDK2 (0.46) | ALKBH5NOTUMFLT1KDRHSD11B1 | |
| SCHEMBL13485858 | 0.64 | COMT (0.56) | ALKBH5NOTUMFLT1KDRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |