Sugi Predict

Sugi Predict / Compounds / SCHEMBL7185481

SCHEMBL7185481

SCHEMBL7185481

COc1cc(OC)c(C(=O)[P](=O)c2ccccc2C(=O)c2c(Br)cccc2Br)c(OC)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 2/20 0.40
▸ RAB9A P51151 2/20 0.40
▸ ABCG2 Q9UNQ0 3/20 0.36
▸ CYP3A4 P08684 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ ATM Q13315 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ HPGD P15428 2/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ USP2 O75604 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ MAOA P21397 1/20 0.36
▸ MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7176979 0.91 CA12 (0.40) NPC1RAB9AKMT2AALDH1A1HPGD
SCHEMBL7188977 0.89 MAPT (0.41) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7736110 0.87 ALDH1A1 (0.43) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7175462 0.86 KMT2A (0.45) NPC1ABCG2CYP3A4KMT2ATP53
SCHEMBL7181292 0.85 ALDH1A1 (0.38) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7177204 0.85 PKM (0.38) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7180294 0.84 ALDH1A1 (0.43) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7182505 0.84 KMT2A (0.40) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7188172 0.83 SMN1; SMN2 (0.38) NPC1RAB9AABCG2CYP3A4KMT2A
SCHEMBL7182106 0.83 KMT2A (0.45) NPC1ABCG2CYP3A4KMT2ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 NPC1 772/4885RAB9A 1818/4885ABCG2 3732/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 NPC1 872/4885RAB9A 2155/4885ABCG2 4323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.