Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185655 | 0.90 | PTPN1 (0.32) | MAPTHPGDALDH1A1 | |
| SCHEMBL7187611 | 0.79 | CD274 (0.39) | ALDH1A1 | |
| SCHEMBL7189759 | 0.77 | ALDH1A1 (0.40) | MAPTHPGDALDH1A1LMNA | |
| SCHEMBL7183224 | 0.76 | CYP2D6 (0.36) | MAPTLMNA | |
| SCHEMBL7185646 | 0.75 | PTPN1 (0.54) | — | |
| SCHEMBL7201250 | 0.73 | KMT2A (0.38) | MAPTHPGDALDH1A1LMNATSHR | |
| SCHEMBL7184328 | 0.73 | CYP1A2 (0.45) | MAPTHPGDALDH1A1LMNA | |
| SCHEMBL7599157 | 0.73 | PTPN1 (0.36) | MAPTHPGDALDH1A1 | |
| SCHEMBL7200760 | 0.73 | — | — | |
| SCHEMBL7189783 | 0.72 | CYP2D6 (0.44) | HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |