SCHEMBL7184328

SCHEMBL7184328

O=[N+]([O-])c1ccc(CSCc2ccc(OP(=O)(Oc3ccc(CSCc4ccc([N+](=O)[O-])cc4)cc3Br)C(F)F)c(Br)c2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.45
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
MAPT P10636 6/20 0.39
ALDH1A1 P00352 5/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
HTR2A P28223 1/20 0.38
LMNA P02545 4/20 0.38
HPGD P15428 2/20 0.37
THRB P10828 1/20 0.37
HTT P42858 1/20 0.37
IDO1 P14902 2/20 0.36
AKR1C3 P42330 1/20 0.36
CCR5 P51681 1/20 0.36
POLB P06746 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
BCHE P06276 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7184334 0.89 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19MAPTALDH1A1
SCHEMBL7183224 0.80 CYP2D6 (0.36) CYP1A2CYP2C9CYP2C19MAPTSMN1; SMN2
SCHEMBL7603810 0.80 CCR5 (0.39) MAPTALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL7187611 0.75 CD274 (0.39) ALDH1A1KMT2ACA1CA2
SCHEMBL7194652 0.74 CCR5 (0.37) MAPTALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL7189291 0.73 ALDH1A1 (0.31) ALDH1A1
SCHEMBL7185652 0.73 MAPT (0.32) MAPTALDH1A1LMNAHPGD
SCHEMBL7201250 0.73 KMT2A (0.38) CYP1A2MAPTALDH1A1KMT2AMEN1
SCHEMBL7193736 0.73 PTPN1 (0.38) CYP1A2CYP2C9CYP2C19MAPTALDH1A1
SCHEMBL7183011 0.73 PTPN1 (0.38) CYP1A2CYP2C9CYP2C19MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268494-A1 SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS Merck Frosst Canada & Co. (CA) 2003-01-02 EP disclosed
WO-2001070753-A1 SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS MERCK FROSST CANADA & CO. (CA) 2001-09-27 WO disclosed