SCHEMBL7186276

SCHEMBL7186276

Clc1ccc(N2CCCCCC2)cn1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 6/20 0.56
CHRNA3 P32297 6/20 0.56
CHRNB2 P17787 6/20 0.53
CHRNA4 P43681 6/20 0.53
POLB P06746 2/20 0.53
MAPT P10636 1/20 0.53
AKR1C3 P42330 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29932734 1.00 CHRNB4 (0.56) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL27594106 0.98 CHRNB4 (0.58) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL27057850 0.94 CHRNB4 (0.58) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL29998481 0.90 CHRNB4 (0.61) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL3060400 0.83 CHRNB2 (0.68) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL2001588 0.82 CHRNB4 (0.54) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL29552004 0.81 AKR1C3 (0.70) CHRNB4CHRNA3CHRNB2CHRNA4POLB
SCHEMBL2923088 0.81 CHRNB2 (0.64) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL1321991 0.81 AKR1C3 (0.54) CHRNB4CHRNA3CHRNB2CHRNA4MAPT
SCHEMBL5198623 0.81 AKR1C3 (0.70) CHRNB4CHRNA3CHRNB2CHRNA4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed