Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.30 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719516 | 0.84 | TDP1 (0.47) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL5138267 | 0.81 | TDP1 (0.37) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL29372042 | 0.81 | PDE10A (0.46) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL287902 | 0.81 | PDE10A (0.46) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL4430199 | 0.80 | PDE10A (0.48) | PDE4BPDE4DPDE10A | |
| SCHEMBL16245461 | 0.79 | PDE10A (0.45) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL1535584 | 0.79 | PDE10A (0.45) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| Water SCHEMBL1581295 | 0.79 | PDE10A (0.45) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL5752308 | 0.78 | TDP1 (0.42) | TDP1PDE4BPDE4DPDE10AHCAR2 | |
| SCHEMBL1609597 | 0.76 | PDE10A (0.46) | PDE4BPDE4DPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102395568-A | Pyrimidine derivatives and their use as herbicides | SYNGENTA LTD | 2012-03-28 | — | — | CN | disclosed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | disclosed |
| EP-2396306-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | Syngenta Limited (GB) | 2011-12-21 | — | — | EP | disclosed |
| US-20110086759-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086759-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086759-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-04-14 | — | — | US | disclosed |
| CN-101938905-A | Chemical compounds | SYNGENTA LTD | 2011-01-05 | — | — | CN | disclosed |
| EP-2237669-A2 | CHEMICAL COMPOUNDS | Syngenta Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2010092339-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
| WO-2009081112-A2 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086759-A1 | CHEMICAL COMPOUNDS | DDT, PNPO, CBR3 | TDP1 344/4885PDE4B 1132/4885PDE4D 2126/4885 |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | DPYD, DHODH, TYMP | TDP1 274/4885PDE4B 1078/4885PDE4D 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.