Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 3/20 | 0.41 |
| ▸ | OXTR | P30559 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.38 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.38 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169709 | 0.84 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7194424 | 0.83 | PSEN1 (0.52) | CCKBROXTRKCNH2PSEN1PSEN2 | |
| SCHEMBL6006721 | 0.80 | CCKBR (0.66) | CCKBROXTRKCNH2PSEN1PSEN2 | |
| SCHEMBL6006714 | 0.80 | CCKBR (0.66) | CCKBROXTRKCNH2PSEN1PSEN2 | |
| SCHEMBL7168170 | 0.80 | CCKBR (0.39) | CCKBRKCNH2NOTCH1RBPJSCN9A | |
| SCHEMBL7192961 | 0.78 | NOTCH1 (0.41) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7163376 | 0.78 | CCKBR (0.39) | CCKBRKCNH2NOTCH1SCN9A | |
| SCHEMBL7170270 | 0.77 | PSEN1 (0.50) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7163053 | 0.76 | PSEN1 (0.55) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL7166155 | 0.75 | PSEN1 (0.46) | CCKBRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |