Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1678495 | 0.87 | LOXL2 (0.48) | LOXL2HRH1AKT1ALDH1A1HRH3 | |
| SCHEMBL10910996 | 0.82 | LOXL2 (0.44) | LOXL2HRH1AKT1ALDH1A1ERAP2 | |
| SCHEMBL31223729 | 0.82 | LOXL2 (0.52) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22229846 | 0.82 | LOXL2 (0.52) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1677867 | 0.82 | LOXL2 (0.52) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL18191799 | 0.80 | LOXL2 (0.50) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| Hydrazine SCHEMBL2567860 | 0.79 | LOXL2 (0.48) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19090267 | 0.79 | LOXL2 (0.48) | LOXL2HRH1AKT1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8535371 | 0.77 | LOXL2 (0.47) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28174568 | 0.77 | LOXL2 (0.47) | LOXL2HRH1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946190-B1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE OUTGROWTH | VERTEX PHARMA (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-0946190-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998020891-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | disclosed |