Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187179 | 1.00 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1APP | |
| SCHEMBL2728614 | 0.93 | HCAR3 (0.64) | HCAR3ALDH1A1WNK1L3MBTL1APP | |
| SCHEMBL7541568 | 0.86 | HCAR3 (0.64) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL17675674 | 0.84 | HCAR3 (0.55) | HCAR3ALDH1A1WNK1L3MBTL1APP | |
| SCHEMBL7180257 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL21293972 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL7180261 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL21294007 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL20096272 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT | |
| SCHEMBL29741389 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1WNK1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |