Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7180257 | 1.00 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7479621 | 0.87 | HCAR3 (0.66) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13500566 | 0.86 | HCAR3 (0.64) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7187179 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL21294007 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7187183 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL29741389 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL21293972 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL20096272 | 0.83 | HCAR3 (0.60) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7191851 | 0.83 | HCAR3 (0.71) | HCAR3ALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |