Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047898 | 0.85 | CYP1A2 (0.62) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL5830948 | 0.81 | GPR84 (0.59) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL9800436 | 0.81 | CYP1A2 (0.58) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL780469 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL128331 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL134400 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL2165102 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL5254582 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL27549 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 | |
| SCHEMBL134399 | 0.77 | CYP1A2 (0.54) | CYP1A2CYP2C19CYP2C9NQO2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-54005957-A | — | — | None | — | — | JP | disclosed |
| US-8575393-B2 | Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process | CIPLA LIMITED (IN) | 2013-11-05 | — | — | US | disclosed |
| US-20120053362-A1 | Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process | CIPLA LIMITED (IN) | 2012-03-01 | — | — | US | disclosed |
| EP-2403823-A2 | PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS | Cipla Limited (IN) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100429-A1 | PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS | CIPLA LIMITED (IN) | 2010-09-10 | — | — | WO | disclosed |
| JP-S545957-A | RACEMIZATION OF OPTICAL ACTIVE ALPHA-NAPHTHYLETHYLAMINE | SUMITOMO CHEM CO LTD | 1979-01-17 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053362-A1 | Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process | CA4, CA9, SLC28A1 | CYP1A2 779/4885CYP2C19 262/4885CYP2C9 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.