Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL6 | P05231 | 1/20 | 0.39 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | GLUL | P15104 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7132288 | 1.00 | LMNA (0.47) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL7137249 | 0.92 | LMNA (0.48) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| Bicarbonate SCHEMBL7130344 | 0.88 | LMNA (0.42) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL7081750 | 0.84 | LMNA (0.52) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL15994233 | 0.81 | LMNA (0.51) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL7136967 | 0.79 | LMNA (0.48) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL7135801 | 0.77 | LMNA (0.49) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL4218774 | 0.76 | LMNA (0.52) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL4220943 | 0.76 | LMNA (0.52) | LMNAMAPTCYP19A1NR3C1HIF1A | |
| SCHEMBL7076650 | 0.75 | LMNA (0.46) | LMNAMAPTCYP19A1NR3C1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003062259-A2 | NON-AROMATIC 17.ALPHA.-ESTERS OF ANDROSTANE-17.BETA.-CARBOXYLATE ESTERS AS ANTI-INFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 2003-07-31 | — | — | WO | disclosed |