Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | PGK1 | P00558 | 2/20 | 0.37 |
| ▸ | PGK2 | P07205 | 2/20 | 0.37 |
| ▸ | PTPRB | P23467 | 3/20 | 0.37 |
| ▸ | PTPRC | P08575 | 3/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598722 | 0.86 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7198599 | 0.83 | PTPN1 (0.43) | PTPN1PTPN2PTPRCALDH1A1 | |
| SCHEMBL5893048 | 0.79 | RXRA (0.46) | PTPN1ALDH1A1TSHR | |
| SCHEMBL5162409 | 0.77 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL14076471 | 0.77 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7182139 | 0.77 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11IDO1 | |
| SCHEMBL3740693 | 0.77 | FFAR1 (0.46) | PTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL2423462 | 0.76 | PTPN1 (0.67) | PTPN1PTPRCALDH1A1 | |
| SCHEMBL7876107 | 0.76 | PTPN1 (0.67) | PTPN1PTPRCALDH1A1 | |
| SCHEMBL7639389 | 0.76 | PTPN1 (0.43) | PTPN1PTPN2PTPN6PTPN11PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | PTPN1 13/4885PTPN2 24/4885PTPN6 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.