SCHEMBL7187995

SCHEMBL7187995

CCC(NC(=O)C(CS(=O)(=O)c1ccccc1OC)NC(=O)N(C)C)C(=O)c1nc2ccccc2o1

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CTSS P25774 20/20 0.45
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CTSL P07711 1/20 0.40
CTSB P07858 1/20 0.40
CTSK P43235 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187997 1.00 CTSS (0.45) CTSSCYP3A4CYP2C9CTSLCTSB
SCHEMBL6478314 0.87 CTSS (0.42) CTSSCYP3A4CYP2C9
SCHEMBL7045307 0.87 CTSS (0.42) CTSSCYP3A4CYP2C9
SCHEMBL7188004 0.84 FAAH (0.39) CTSS
SCHEMBL5422050 0.76 CTSS (0.42) CTSSCYP3A4CYP2C9CTSK
SCHEMBL6467432 0.76 P2RY14 (0.37) CTSSCYP3A4CYP2C9CTSK
SCHEMBL7045310 0.71 FAAH (0.38) CTSS
SCHEMBL27663441 0.71 CTSS (0.57) CTSSCYP3A4CYP2C9
SCHEMBL6467430 0.70 P2RY14 (0.35) CYP3A4
SCHEMBL5422852 0.69 CTSS (0.52) CTSSCYP3A4CYP2C9CTSLCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6576630-B1 Alkanoyl substituted benzooxazoles or naphthooxazoles AXYS PHARMACEUTICALS, INC. 2003-06-10 US disclosed