Sugi Predict

Sugi Predict / Compounds / Lithium

Lithium

Lithium

SCHEMBL7188166

O=C(Pc1ccccc1-c1ccccc1)c1c(Cl)cccc1Cl.[Li]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.46
▸ ALDH1A1 P00352 4/20 0.40
▸ FABP3 P05413 2/20 0.40
▸ FABP4 P15090 2/20 0.40
▸ KDM4E B2RXH2 1/20 0.38
▸ APAF1 O14727 1/20 0.38
▸ TDP2 O95551 1/20 0.38
▸ NSD2 O96028 1/20 0.38
▸ ABL1 P00519 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ GALK1 P51570 1/20 0.38
▸ BLM P54132 1/20 0.38
▸ RIN1 Q13671 1/20 0.38
▸ SENP8 Q96LD8 1/20 0.38
▸ SENP7 Q9BQF6 1/20 0.38
▸ SENP6 Q9GZR1 1/20 0.38
▸ ELANE P08246 1/20 0.38
▸ HNF4A P41235 1/20 0.38
▸ LMNA P02545 2/20 0.37
▸ NPY1R P25929 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188157 0.97 CYP2A6 (0.46) CYP2A6ALDH1A1FABP3FABP4KDM4E
Lithium SCHEMBL7179768 0.92 FABP3 (0.46) CYP2A6FABP3FABP4KDM4EMAPT
Lithium SCHEMBL7177166 0.89 FABP4 (0.47) ALDH1A1FABP3FABP4KDM4EMAPT
SCHEMBL7179761 0.89 FABP3 (0.46) CYP2A6FABP3FABP4KDM4EMAPT
SCHEMBL7177161 0.86 FABP4 (0.47) ALDH1A1FABP3FABP4KDM4EMAPT
Lithium SCHEMBL7180240 0.83 MYC (0.39) ALDH1A1FABP3FABP4KDM4EMAPT
SCHEMBL7180235 0.79 MYC (0.39) ALDH1A1FABP3FABP4KDM4EMAPT
Lithium SCHEMBL7179357 0.79 CA12 (0.47) ALDH1A1FABP3FABP4KDM4EMAPT
Lithium SCHEMBL7175228 0.79 SLC13A5 (0.39) ALDH1A1FABP4LMNA
Lithium SCHEMBL7174791 0.77 LMNA (0.40) ALDH1A1LMNAL3MBTL1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 CYP2A6 1731/4885ALDH1A1 3416/4885FABP3 3252/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 CYP2A6 1937/4885ALDH1A1 3984/4885FABP3 2807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.