Sugi Predict

Sugi Predict / Compounds / SCHEMBL7188326

SCHEMBL7188326

SCHEMBL7188326

COc1ccc(OC)c(C(=O)c2ccccc2[P](=O)C(=O)c2c(C)cccc2C)c1OC

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ PTPN1 P18031 1/20 0.36
▸ POLB P06746 2/20 0.35
▸ KCNK3 O14649 1/20 0.35
▸ KCNK9 Q9NPC2 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA7 P43166 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ CA14 Q9ULX7 1/20 0.34
▸ ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189001 0.91 CA12 (0.40) KMT2AMEN1PTPN1POLBALDH1A1
SCHEMBL7179534 0.91 ABCB1 (0.39) KMT2AMEN1PTPN1ALDH1A1NPC1
SCHEMBL7177390 0.88 CA12 (0.41) KMT2APOLBKCNK3KCNK9ALDH1A1
SCHEMBL7186774 0.87 KMT2A (0.39) KMT2AMEN1ALDH1A1NPC1RAB9A
SCHEMBL7189615 0.86 PTPN1 (0.33) KMT2AMEN1PTPN1POLBALDH1A1
SCHEMBL7188172 0.86 SMN1; SMN2 (0.38) KMT2AMEN1PTPN1ALDH1A1NPC1
SCHEMBL7722891 0.85 MAOB (0.39) KMT2AMEN1POLBALDH1A1KDM4E
SCHEMBL7180294 0.84 ALDH1A1 (0.43) KMT2AMEN1POLBKCNK3KCNK9
SCHEMBL7180488 0.82 ABCB1 (0.43) KMT2AMEN1POLBKCNK3KCNK9
SCHEMBL7736110 0.82 ALDH1A1 (0.43) KMT2AMEN1POLBKCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885MEN1 2312/4885PTPN1 487/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885MEN1 2263/4885PTPN1 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.