Sugi Predict

Sugi Predict / Compounds / SCHEMBL7186774

SCHEMBL7186774

SCHEMBL7186774

COc1ccc(OC)c(C(=O)c2ccccc2[P](=O)C(=O)c2c(Cl)cccc2Cl)c1OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.39
▸ CES2 O00748 1/20 0.38
▸ CES1 P23141 1/20 0.38
▸ TUBB4A P04350 2/20 0.38
▸ TUBB P07437 2/20 0.38
▸ TUBA3C P0DPH7 2/20 0.38
▸ TUBA1B P68363 2/20 0.38
▸ TUBA4A P68366 2/20 0.38
▸ TUBB4B P68371 2/20 0.38
▸ TUBB3 Q13509 2/20 0.38
▸ TUBB2A Q13885 2/20 0.38
▸ TUBB8 Q3ZCM7 2/20 0.38
▸ TUBA3E Q6PEY2 2/20 0.38
▸ TUBA1A Q71U36 2/20 0.38
▸ TUBA1C Q9BQE3 2/20 0.38
▸ TUBB6 Q9BUF5 2/20 0.38
▸ TUBB2B Q9BVA1 2/20 0.38
▸ TUBB1 Q9H4B7 2/20 0.38
▸ LMNA P02545 3/20 0.38
▸ TOP1 P11387 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189001 0.90 CA12 (0.40) KMT2ALMNARAB9ANPC1MEN1
SCHEMBL7186470 0.88 RORC (0.42) KMT2ACES2CES1TUBB4ATUBB
SCHEMBL7188326 0.87 KMT2A (0.36) KMT2ALMNATOP1RAB9ANPC1
SCHEMBL7188172 0.85 SMN1; SMN2 (0.38) KMT2ATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7182106 0.85 KMT2A (0.45) KMT2ACES2CES1TUBB4ATUBB
SCHEMBL7722891 0.84 MAOB (0.39) KMT2ALMNAMEN1ALDH1A1SMN1; SMN2
SCHEMBL7189134 0.83 CA12 (0.40) KMT2ALMNARAB9ANPC1MEN1
SCHEMBL7179534 0.83 ABCB1 (0.39) KMT2ALMNARAB9ANPC1MEN1
SCHEMBL7175462 0.82 KMT2A (0.45) KMT2ACES2CES1TUBB4ATUBB
SCHEMBL7174638 0.82 HPGD (0.38) KMT2ACES2CES1LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885CES2 1571/4885CES1 405/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885CES2 1260/4885CES1 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.