Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116538 | 0.84 | MAPK1 (0.62) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL7192206 | 0.83 | KMT2A (0.52) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL4393879 | 0.82 | MAPT (0.54) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL4393888 | 0.82 | MAPT (0.54) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL5052131 | 0.81 | MAPK1 (0.55) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL7955855 | 0.81 | MAPK1 (0.55) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL3083108 | 0.81 | KDM4E (0.47) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL27756751 | 0.79 | KMT2A (0.48) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL1855646 | 0.79 | MAPT (0.50) | MAPK1KMT2APKMMEN1MAPT | |
| SCHEMBL1855648 | 0.79 | MAPT (0.50) | MAPK1KMT2APKMMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |