Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116538 | 0.84 | MAPK1 (0.62) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL7188544 | 0.81 | MAPK1 (0.55) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL7350226 | 0.79 | MAPT (0.65) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL7354885 | 0.78 | KMT2A (0.58) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL5052131 | 0.78 | MAPK1 (0.55) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL4490148 | 0.78 | MAPK1 (0.61) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL116971 | 0.78 | MAPK1 (0.65) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL28300949 | 0.78 | MAPK1 (0.61) | MAPK1MAPTALDH1A1KCNMA1PKM | |
| SCHEMBL7955876 | 0.77 | ALDH1A1 (0.48) | MAPTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL7355650 | 0.77 | MAPT (0.62) | MAPK1MAPTALDH1A1KCNMA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| CN-1038840-C | para-dinitrogen naphthalene derivative, its preparation method and its medical use | SCHERING AG (DE) | 1998-06-24 | — | — | CN | disclosed |