Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.48 |
| ▸ | NOS1 | P29475 | 7/20 | 0.48 |
| ▸ | NOS2 | P35228 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219973 | 0.96 | NOS3 (0.52) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL7188765 | 0.90 | MEN1 (0.46) | MEN1KMT2AL3MBTL1TDP1ABCB1 | |
| SCHEMBL4284903 | 0.83 | NOS1 (0.54) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL221914 | 0.82 | NOS3 (0.63) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL27981986 | 0.80 | MEN1 (0.51) | MEN1KMT2AL3MBTL1TDP1ABCB1 | |
| SCHEMBL6583956 | 0.78 | NOS1 (0.48) | NOS3NOS1NOS2L3MBTL1 | |
| SCHEMBL5833752 | 0.78 | NOS3 (0.74) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL221387 | 0.78 | NOS1 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL5833630 | 0.78 | NOS3 (0.69) | NOS3NOS1NOS2ABCB1KDM4E | |
| SCHEMBL5833404 | 0.76 | NOS3 (0.76) | NOS3NOS1NOS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045449-A1 | Pharmaceutical combinations for the treatment of neurodegenerative diseases | PFIZER, INC. | 2003-03-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045449-A1 | Pharmaceutical combinations for the treatment of neurodegenerative diseases | GRIN3A, GRIN1, CHRNA10 | NOS3 157/4885NOS1 110/4885NOS2 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.