Sugi Predict

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Lithium

Lithium

SCHEMBL7188967

Cc1cc(C)c(C(=O)Pc2ccc(OC(C)C)cc2OC(C)C)c(C)c1.[Li]

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR4 Q5NUL3 2/20 0.39
▸ TSPO P30536 2/20 0.39
▸ ALDH1A1 P00352 5/20 0.37
▸ MAPT P10636 4/20 0.37
▸ GAA P10253 2/20 0.37
▸ POLB P06746 1/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ PARP10 Q53GL7 1/20 0.35
▸ HPGD P15428 3/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ MCL1 Q07820 1/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ NLRP1 Q9C000 1/20 0.33
▸ MCOLN3 Q8TDD5 1/20 0.33
▸ IRAK4 Q9NWZ3 1/20 0.33
▸ NPY1R P25929 1/20 0.33
▸ NPY2R P49146 1/20 0.33
▸ LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188960 0.97 FFAR4 (0.39) FFAR4TSPOALDH1A1MAPTGAA
Lithium SCHEMBL7177679 0.90 ALDH1A1 (0.37) FFAR4TSPOALDH1A1MAPTGAA
Lithium SCHEMBL7187691 0.89 NR1H4 (0.39) TSPOALDH1A1MAPTPOLBKMT2A
Lithium SCHEMBL7177970 0.87 ALDH1A1 (0.35) FFAR4TSPOALDH1A1MAPTGAA
SCHEMBL7177670 0.87 ALDH1A1 (0.37) FFAR4TSPOALDH1A1MAPTGAA
SCHEMBL7182015 0.86 FFAR4 (0.41) FFAR4TSPOALDH1A1MAPTGAA
SCHEMBL7187681 0.86 NR1H4 (0.39) TSPOALDH1A1MAPTPOLBKMT2A
Lithium SCHEMBL7179682 0.85 ACACB (0.34) TSPOMAPTKMT2AHPGDNPSR1
SCHEMBL7182436 0.85 L3MBTL1 (0.34) FFAR4TSPOALDH1A1KMT2AHPGD
SCHEMBL7177965 0.85 ALDH1A1 (0.35) FFAR4TSPOALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1200943-C Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2005-05-11 — — CN disclosed
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed
CN-1308081-A Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2001-08-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 FFAR4 1611/4885TSPO 3188/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 FFAR4 1526/4885TSPO 2597/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.