SCHEMBL7189549

SCHEMBL7189549

COc1cc(OC)c(C(=O)Pc2ccc(OCc3ccccc3)cc2OCc2ccccc2)c(OC)c1.[LiH]

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.46
MAOB P27338 4/20 0.46
HDAC8 Q9BY41 1/20 0.46
TDP1 Q9NUW8 1/20 0.45
MTNR1A P48039 1/20 0.44
MTNR1B P49286 1/20 0.44
RXRA P19793 1/20 0.44
PPARA Q07869 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
GAA P10253 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
FLT3 P36888 1/20 0.43
ATM Q13315 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lithium SCHEMBL7189555 0.98 MAOB (0.46) L3MBTL1MAOBHDAC8TDP1RXRA
SCHEMBL7187430 0.93 L3MBTL1 (0.49) L3MBTL1MAOBHDAC8RXRAPPARA
SCHEMBL7179771 0.91 L3MBTL1 (0.45) L3MBTL1MAOBHDAC8TDP1NPC1
Lithium SCHEMBL7187439 0.91 MRGPRX4 (0.47) L3MBTL1MAOBHDAC8RXRAPPARA
SCHEMBL7175247 0.87 L3MBTL1 (0.46) L3MBTL1MAOBHDAC8RXRAKDM4E
SCHEMBL7179980 0.86 RXRA (0.46) L3MBTL1MAOBHDAC8TDP1MTNR1A
SCHEMBL7181827 0.86 L3MBTL1 (0.51) L3MBTL1MAOBHDAC8TDP1NPC1
SCHEMBL7177769 0.85 MAOB (0.48) L3MBTL1MAOBRXRA
Lithium SCHEMBL7175251 0.85 MRGPRX4 (0.44) L3MBTL1MAOBHDAC8RXRAKDM4E
SCHEMBL7181059 0.84 MAOB (0.46) L3MBTL1MAOBTDP1RXRANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 L3MBTL1 302/4885MAOB 4189/4885HDAC8 1695/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 L3MBTL1 126/4885MAOB 4319/4885HDAC8 1635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.