Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 1.00 |
| ▸ | CA12 | O43570 | 4/20 | 1.00 |
| ▸ | CA2 | P00918 | 4/20 | 1.00 |
| ▸ | CA9 | Q16790 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437620 | 1.00 | CA1 (1.00) | CA1CA12CA2CA9KMT2A | |
| Hydrochloric Acid SCHEMBL28023173 | 0.98 | CA1 (0.96) | CA1CA12CA2CA9KMT2A | |
| SCHEMBL6496816 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9LMNA | |
| SCHEMBL2776254 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9LMNA | |
| SCHEMBL28961017 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9KMT2A | |
| SCHEMBL2777400 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9LMNA | |
| SCHEMBL6494977 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9KMT2A | |
| SCHEMBL6505477 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9LMNA | |
| SCHEMBL30070404 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9KMT2A | |
| SCHEMBL10082924 | 0.73 | CA1 (0.58) | CA1CA12CA2CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113773277-B | Synthesis method of 4H-1,2, 4-benzothiadiazine-1, 1-dioxide derivative | 兰州大学 | 2023-12-05 | — | — | CN | claimed |
| CN-113773277-A | Synthetic method of 4H-1,2, 4-benzothiadiazine-1, 1-dioxide derivative | 兰州大学 | 2021-12-10 | — | — | CN | claimed |
| CN-104761514-B | 1,1-dioxo-4H-benzo [1,2,4]-thiadiazine hydrochlorate compounds and preparation method thereof | 河南师范大学 | 2016-11-23 | — | — | CN | claimed |
| US-20120053172-A1 | USE OF A COMBINATION OF DIAZOXIDE AND METFORMIN FOR TREATING OBESITY OR OBESITY RELATED DISORDERS | COOPERATIEVE MIRZORG U.A. | 2012-03-01 | — | — | US | claimed |
| US-20100234362-A1 | USE OF DIAZOXIDE FOR SUPPRESSING THE PLASMA INSULIN LEVEL IN A MAMMAL | COOPERATIEVE MIRZORG U.A. (NL) | 2010-09-16 | — | — | US | claimed |
| EP-1348702-B1 | Method of producing 1, 2, 4-benzothiadiazine-1, 1-dioxide compound | FUJI PHOTO FILM CO LTD (JP) | 2006-12-20 | — | — | EP | claimed |
| EP-1348702-A1 | Method of producing 1, 2, 4-benzothiadiazine-1, 1-dioxide compound | FUJI PHOTO FILM CO., LTD. (JP) | 2003-10-01 | — | — | EP | claimed |
| CN-1293665-A | New compounds and their use as positive AMPA receptor modulators | NEUROSEARCH AS (DK) | 2001-05-02 | — | — | CN | claimed |
| WO-2000048559-A2 | COMPOSITION FOR PROMOTING HAIR GROWTH COMPRISING DERIVATIVES OF VITAMINS AND DMSO | JONES MARCUS R (US) | 2000-08-24 | — | — | WO | claimed |
| US-5885760-A | ON CHROMOGENIC DEVELOPMENT, COLOR IMAGES HAVING IMPROVED GRAINS | AGFA-GEVAERT AG (DE) | 1999-03-23 | — | — | US | claimed |
| EP-0276151-B1 | Dissolved composition of [benzo-1,2,4-thiadiazine]-1,1-dioxide for hair germination and hair growth promotion. | SHISEIDO COMPANY LIMITED (JP) | 1993-08-04 | — | — | EP | claimed |
| EP-0222670-B1 | DISSOLVED COMPOSITION OF (BENZO-1,2,4-THIADIAZINE)-1,1-DIOXIDE | SHISEIDO COMPANY LIMITED (JP) | 1991-01-16 | — | — | EP | claimed |
| US-4985425-A | HAIR GROWTH | SHISEIDO COMPANY LTD. (JP) | 1991-01-15 | — | — | US | claimed |
| WO-1988005653-A1 | TOPICAL COMPOSITION FOR STIMULATING HAIR GROWTH WITH STABLE FREE RADICALS | PROCTOR PETER H (US) | 1988-08-11 | — | — | WO | claimed |
| EP-0276151-A2 | Dissolved composition of [benzo-1,2,4-thiadiazine]-1,1-dioxide for hair germination and hair growth promotion. | SHISEIDO COMPANY LIMITED (JP) | 1988-07-27 | — | — | EP | claimed |
| EP-0222670-A1 | Dissolved composition of (benzo-1,2,4-thiadiazine)-1,1-dioxide | SHISEIDO COMPANY LIMITED (JP) | 1987-05-20 | — | — | EP | claimed |
| US-4576941-A | Compounds for treating hypertension | USV PHARMACEUTICAL CORP. (US) | 1986-03-18 | — | — | US | claimed |
| US-4260744-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-04-07 | — | — | US | claimed |
| JP-63096118-A | — | — | None | — | — | JP | disclosed |
| US-3793318-A | 1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE DERIVATIVES | LAFON SA LAB | 1974-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053172-A1 | USE OF A COMBINATION OF DIAZOXIDE AND METFORMIN FOR TREATING OBESITY OR OBESITY RELATED DISORDERS | GPR119, KCNJ1, GLP1R | CA1 3123/4885CA12 4023/4885CA2 544/4885 |
| US-20100234362-A1 | USE OF DIAZOXIDE FOR SUPPRESSING THE PLASMA INSULIN LEVEL IN A MAMMAL | KCNN4, KCNN1, GPR119 | CA1 2370/4885CA12 3623/4885CA2 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.