Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluphenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 7/20 | 0.98 |
| ▸ | MAPT | P10636 | 7/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.98 |
| ▸ | USP2 | O75604 | 5/20 | 0.98 |
| ▸ | TP53 | P04637 | 4/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | HTR1A | P08908 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.98 |
| ▸ | HTR2A | P28223 | 3/20 | 0.98 |
| ▸ | HTR2C | P28335 | 3/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluphenazine SCHEMBL7194249 | 0.99 | LMNA (0.98) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL29388890 | 0.99 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL29354183 | 0.99 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL5072860 | 0.99 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL19221 | 0.99 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL41634 | 0.98 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL1496274 | 0.98 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL2560022 | 0.98 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL28642082 | 0.98 | LMNA (0.98) | LMNAMAPTCYP3A4MAPK1USP2 | |
| Fluphenazine SCHEMBL41635 | 0.98 | LMNA (1.00) | LMNAMAPTCYP3A4MAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003035596-A2 | INHIBITOR MIXTURE FOR (METH)ACRYLIC ACID AND (METH)ACRYLIC ACID ESTER | BASF AKTIENGESELLSCHAFT (DE) | 2003-05-01 | — | — | WO | claimed |