Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 17/20 | 0.59 |
| ▸ | THRB | P10828 | 17/20 | 0.59 |
| ▸ | PCNA | P12004 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7194241 | 0.89 | THRA (0.74) | THRATHRB | |
| SCHEMBL5388459 | 0.85 | THRB (0.81) | THRATHRBPCNAPOLBMAPK1 | |
| SCHEMBL5387098 | 0.84 | THRB (0.73) | THRATHRBPCNAPOLBMAPK1 | |
| SCHEMBL4566353 | 0.78 | THRB (0.56) | THRATHRB | |
| SCHEMBL5386315 | 0.77 | THRA (0.55) | THRATHRBPCNAPOLBMAPK1 | |
| SCHEMBL3136249 | 0.75 | THRB (0.79) | THRATHRB | |
| SCHEMBL5392866 | 0.74 | THRA (1.00) | THRATHRB | |
| SCHEMBL5387389 | 0.74 | THRA (0.88) | THRATHRB | |
| SCHEMBL7073265 | 0.74 | THRB (0.76) | THRATHRB | |
| SCHEMBL7069853 | 0.73 | THRA (1.00) | THRATHRBPCNAPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |