Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 11/20 | 0.58 |
| ▸ | PNP | P00491 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TK1 | P04183 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | POLA1 | P09884 | 1/20 | 0.56 |
| ▸ | POLG | P54098 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL5930250 | 0.99 | HPRT1 (0.57) | HPRT1PNPPOLBTK1MEN1 | |
| SCHEMBL12732295 | 0.92 | HPRT1 (0.57) | HPRT1PNPPOLBTK1MEN1 | |
| Penciclovir Triphosphate SCHEMBL1664402 | 0.91 | POLG (0.65) | HPRT1PNPPOLBTK1MEN1 | |
| Penciclovir Triphosphate SCHEMBL30945294 | 0.91 | POLG (0.65) | HPRT1PNPPOLBTK1MEN1 | |
| SCHEMBL9824169 | 0.91 | HPRT1 (0.60) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Penciclovir SCHEMBL4240104 | 0.90 | HPRT1 (0.66) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Penciclovir SCHEMBL454090 | 0.90 | HPRT1 (0.66) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL12800326 | 0.89 | HPRT1 (0.57) | HPRT1PNPPOLBTK1MEN1 | |
| Penciclovir SCHEMBL3495 | 0.88 | TK1 (0.70) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL15340416 | 0.87 | HPRT1 (0.55) | HPRT1PNPPOLBPOLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |
| US-6579981-B1 | Treating herpes virus | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2003-06-17 | — | — | US | disclosed |
| US-6573378-B1 | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine having a purity of greater than 95% by weight or it's sodium salt | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2003-06-03 | — | — | US | disclosed |
| US-5075445-A | GUANINE DERIVATIVES | BEECHAM GROUP P.L.C. (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0141927-B1 | ANTIVIRAL GUANINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1991-10-30 | — | — | EP | disclosed |
| EP-0152316-B1 | SUBSTITUTED BUTYL GUANINES AND THEIR UTILIZATION IN ANTIVIRAL COMPOSITIONS | MERCK & CO. INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| US-4845084-A | HERPES VIRUSES, AIDS | MERCK & CO., INC. (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0152316-A1 | Substituted butyl guanines and their utilization in antiviral compositions | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |
| EP-0141927-A2 | Antiviral guanine derivatives | BEECHAM GROUP PLC (GB) | 1985-05-22 | — | — | EP | disclosed |