Penciclovir Triphosphate

Penciclovir Triphosphate

SCHEMBL30945294

Nc1nc2c(ncn2CC[C@@H](CO)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)c(=O)[nH]1

nearest known ligand 0.70

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Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.65
PNP P00491 5/20 0.63
POLB P06746 2/20 0.61
POLA1 P09884 1/20 0.61
HPRT1 P00492 9/20 0.54
TK1 P04183 1/20 0.52
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52
CYP3A4 P08684 1/20 0.52
NFKB1 P19838 1/20 0.52
BLM P54132 1/20 0.52
VCP P55072 1/20 0.52
KMT2A Q03164 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HIF1A Q16665 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Penciclovir Triphosphate SCHEMBL1664402 1.00 POLG (0.65) POLGPNPPOLBPOLA1HPRT1
SCHEMBL7196190 0.91 HPRT1 (0.58) POLGPNPPOLBPOLA1HPRT1
Ammonia Solution, Strong SCHEMBL5930250 0.91 HPRT1 (0.57) POLGPNPPOLBPOLA1HPRT1
Ammonia Solution, Strong SCHEMBL7750989 0.90 POLG (0.66) POLGPNPPOLBPOLA1HPRT1
SCHEMBL12800326 0.89 HPRT1 (0.57) POLGPNPPOLBPOLA1HPRT1
SCHEMBL12732295 0.88 HPRT1 (0.57) PNPPOLBHPRT1TK1MEN1
SCHEMBL15630250 0.87 POLG (0.65) POLGPNPPOLBPOLA1HPRT1
SCHEMBL571368 0.87 POLG (0.65) POLGPNPPOLBPOLA1HPRT1
SCHEMBL9824169 0.87 HPRT1 (0.60) PNPHPRT1TK1MEN1ALDH1A1
SCHEMBL15340416 0.86 HPRT1 (0.55) POLGPNPPOLBPOLA1HPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111377926-B Penciclovir crystal form and preparation method thereof 凯默斯医药科技(上海)有限公司 2024-06-07 CN disclosed