Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 9/20 | 0.66 |
| ▸ | FEN1 | P39748 | 9/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.65 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940911 | 0.87 | PTPN1 (0.72) | ERCC5FEN1PTPN1HAO1TDP1 | |
| SCHEMBL6951660 | 0.84 | ERCC5 (0.71) | ERCC5FEN1PTPN1HAO1TDP1 | |
| Dimethylamine SCHEMBL6946035 | 0.84 | PTPN1 (0.68) | ERCC5FEN1PTPN1HAO1 | |
| SCHEMBL12182346 | 0.81 | SMN1; SMN2 (0.51) | ERCC5FEN1PTPN1MEN1MAPT | |
| SCHEMBL11109822 | 0.81 | NPC1 (0.50) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL6946229 | 0.80 | PTPN1 (0.84) | ERCC5FEN1PTPN1SMN1; SMN2RAB9A | |
| SCHEMBL1109671 | 0.80 | ERCC5 (1.00) | ERCC5FEN1PTPN1HAO1TDP1 | |
| SCHEMBL19090371 | 0.79 | SMN1; SMN2 (0.50) | TDP1MAPTHPGDCES1SMN1; SMN2 | |
| SCHEMBL6943340 | 0.79 | PTPN1 (0.74) | ERCC5FEN1PTPN1HAO1KDM4E | |
| SCHEMBL7665038 | 0.79 | PTPN1 (0.74) | ERCC5FEN1PTPN1HAO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | claimed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |