Succinic Acid

Succinic Acid

SCHEMBL7196996

Cc1ccccc1[P+](Cc1ccccc1)(c1ccccc1C)c1ccccc1C.Cc1ccccc1[P+](Cc1ccccc1)(c1ccccc1C)c1ccccc1C.O=C([O-])CCC(=O)[O-]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
POLB P06746 3/20 0.41
ALPL P05186 1/20 0.41
ALPG P10696 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.38
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 2/20 0.36
RECQL P46063 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL7195814 0.91 HDAC3 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
Acetic Acid SCHEMBL8750049 0.90 POLB (0.44) HDAC3HDAC4HDAC1HDAC7HDAC2
Acetic Acid SCHEMBL7197002 0.89 POLB (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
Succinic Acid SCHEMBL7198874 0.86 L3MBTL1 (0.48) L3MBTL1SMN1; SMN2TDP1HPGDALDH1A1
Bromide SCHEMBL6060755 0.83 SNCA (0.39) L3MBTL1ALDH1A1TSHR
Hydrochloric Acid SCHEMBL6060719 0.83 TAAR1 (0.39) L3MBTL1KDM4ETDP1ALDH1A1TSHR
Iodide SCHEMBL6060968 0.83 TAAR1 (0.39) L3MBTL1ALDH1A1TSHR
Succinic Acid SCHEMBL7195815 0.83 TAAR1 (0.43) HDAC1HDAC6POLBCYP1A2KMT2A
Succinic Acid SCHEMBL7200700 0.82 HDAC3 (0.40) HDAC3HDAC4HDAC1HDAC7HDAC2
Phosphoric Acid SCHEMBL7195799 0.82 LAP3 (0.40) POLBALPLALPGL3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0624173-B2 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS DOW CHEMICAL CO (US) 2003-04-09 EP disclosed
EP-0624173-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. DOW CHEMICAL CO (US) 1994-11-17 EP disclosed
WO-1993015126-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS THE DOW CHEMICAL COMPANY (US) 1993-08-05 WO disclosed