SCHEMBL7199169

SCHEMBL7199169

COC(=O)c1ccc(Oc2ccccc2NC(=O)c2cccc(N)c2)cc1C(=O)OC.Nc1cccc(C(=O)Nc2ccccc2Oc2ccc(C(=O)O)c(C(=O)O)c2)c1

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PYGM P11217 10/20 0.71
PYGL P06737 18/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6434067 0.95 PYGM (0.62) PYGMPYGL
SCHEMBL6431989 0.93 PYGL (0.76) PYGMPYGL
SCHEMBL6434074 0.89 PYGM (0.64) PYGMPYGL
SCHEMBL7199970 0.88 PYGL (0.86) PYGMPYGL
SCHEMBL6430901 0.86 PYGM (0.67) PYGMPYGL
SCHEMBL6432820 0.83 PYGM (0.80) PYGMPYGL
SCHEMBL6436695 0.83 PYGM (0.64) PYGMPYGL
SCHEMBL6431628 0.83 PYGM (0.64) PYGMPYGL
SCHEMBL6431624 0.83 PYGM (0.78) PYGMPYGL
SCHEMBL6431378 0.83 PYGM (1.00) PYGMPYGL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6590118-B1 Used in treatment of and/or prevention of diabetes, especially non-insulin dependent diabetes (Type 2 diabetes) NOVO NORDISK A/S (DK) 2003-07-08 US disclosed